Important elements are noteworthy, auxiliary information not so much. Do not let secondary information have a primary role. The hierarchy is one of the most important factors in the content organization and grids are directly connected to it.
A recurring example is when advertising is calling more attention than the subject itself. It can become distracting and cause visual pollution. The example of Zupi Magazine that allocated relevant areas of the grid for advertisements follows below. An alternative is presented by Aesthetica Magazine, which kept its ads grouped in the right part of the grid assuming a secondary role and do not interfering in the information hierarchy.
#2 Think about where you place the elements
The secondary information are in excess and take place in relevant locations on the grid, which undermines the hierarchy of information.
This magazine chose to leave the ads in a secondary part that doesn't directly affect the primary information.